Assistant Professor                                                                                                                

Contact Information:
Email: jbodil@lsuhsc.edu
Office Phone: 318-675-4890                             
Laboratory Phone: 318-675-4862
Office Fax: 318-675-5764

Education/Training

Postdoctoral Study, Northwestern University School of Medicine

Ph.D., Microbiology, 2005, Penn State College of Medicine

M.S., Microbiology, 2000, Brigham Young University

B.S., Molecular Biology, 1999, Brigham Young University

Major Research Interests: Human papillomavirus pathogenesis,
viral-host interactions, viral oncogenesis

Human papillomaviruses (HPVs) are the causative agents of cervical and other cancers.  As part of their normal life cycles, these small DNA viruses infect stratified epithelia and establish persistent infections, usually resulting in minor hyperproliferation, but occasionally progressing to malignancy.  My interest is in the viral-host interactions that enable HPVs to persist and multiply.  We can model all phases of the viral life with both wild-type and genetically modified viruses using a variety of cell culture techniques, including organotypic culture, to establish persistent HPV infections in vitro.  Major life cycle events, functions of viral and host genes, and the host cell response to infection are studied using the techniques of molecular biology, including qPCR, recombinant DNA and site-directed mutagenesis, western blotting, Southern analysis, gel shift, immunoprecipitation, reporter assays, flow cytometry, chromatin immunoprecipitation, and many others.  Current focus in the laboratory is on the interaction of cellular and viral regulatory proteins to control expression of viral late genes, and on how the virus both manipulates and employs host cell cycle and differentiation pathways to ensure its genes are expressed only in the proper place and time.  I am also interested in the manipulation of host responses to hypoxia by HPV and how this may contribute to the development of malignancy.  

Representative Publications:

JM Bodily, DJ Hoopes, BL Roeder, SG Gilbert, GR Pettit, CL Herald, DH Rollins, and RA Robison. The Inhibitory Effects of Bryostatin 1 Administration on the Growth of Rabbit Papillomas. Cancer Letters 136 (1):67-74, 1999.

JL Bromberg-White, E Sen, S Alam, JM Bodily, and C Meyers.  Induction of the Upstream Regulatory Region of Human Papillomavirus Type 31 by Dexamethasone is Differentiation Dependent.  Journal of Virology, 77(20):10975-83, 2003.

JM Bodily and C Meyers.  Genetic Analysis of the Differentiation-dependent HPV31 Late Promoter. Journal of Virology, 79(6):3309-21, 2005.

JM Bodily, S Alam, and C Meyers.  Regulation of Human Papillomavirus Type 31 Late Promoter Activation and Genome Amplification by Protein Kinase C. Virology, 348(2):328-40, 2006.

JM Bodily, M Nakamura, M. Beglin, S Kyo, M Inoue, LA Laimins. Hypoxia-specific stabilization of HIF-1α by human papillomaviruses.  Virology, 387(2):442-8, 2009. 

JM Bodily, KPM Mehta, and LA Laimins.  Human papillomavirus E7 enhances hypoxia inducible factor-1 mediated transcription by inhibiting binding of histone deacetylases.  Cancer Research 71:1187-95, 2011.

JM Bodily, KPM Mehta, L Cruz, C Meyers, and LA Laimins.  The E7 Open Reading Frame Acts in Cis and Trans to Mediate Differentiation-Dependent Activities in the Human Papillomavirus Type 16 Life Cycle, Journal of Virology, 85(17):8852-62, 2011.

All Publications: Pubmed