Professor

Contact Information:
Email: jcarde@lsuhsc.edu
Office Phone: 318-675-5756
Laboratory Phone: 318-675-5769
Office Fax: 318-675-5764

Education/Training:
Postdoctoral Study, University of Wisconsin
Ph.D., 1977, University of Wisconsin, Molecular Biology
B.S, 1973, University of Illinois, Biochemistry and Molecular Biology

Major Research Interests:  Regulation of the invasion and metastasis of cancer cells, and development of novel therapeutics to block or reverse metastatic disease

The major project in my laboratory involves defining the molecular signaling pathways that regulate the invasion and metastasis of cancer cells. Our current primary focus is breast, lung, brain and prostate cancer. Invasion and metastasis are complicated processes that are poorly understood, and they are the primary reasons patients with cancer end up dying. Therefore, a better understanding of these processes will lead to the development of more effective therapies. Our approaches range from 1) basic science to define the role of extracellular tumor environment in regulating changes in lysosome trafficking and cell motility, survival, invasion and metastasis, 2) preclinical testing of novel compounds to block these changes, 3) clinical trials to determine if these compounds actually work in patients with cancer and 4) commercialization of successful compounds.

Recent Representative Publications: 

Bigelow, B. and Cardelli, J. (2006). The Green Tea Catechins, Epigallocatechin-3 gallate (EGCG) and Epicatechin-3 Gallate (ECG) Inhibit HGF/Met Signaling in Breast Epithelial and Tumor Cells. Oncogene 25: 1922-1930.

Snider, J., Bellaire, B. and Cardelli, J. (2008) b1 Integrin Activates JNK Independent of CagA and this is 

Required for Helicobacter pylori CagA+ Induction of Gastric Cancer Cell Motility. J. Biol. Chem. 283: 13952-

13963.

Rupper, A. and Cardelli, J. (2008). Large Scale Purification of Latex Bead Phagosomes from Mouse 

Macrophage Cell Lines and Subsequent Preparation for High-Throughput Quantitative Proteomics. Methods

Mol. Biol. 445: 339-351.

Bigelow, R., Williams, J. Carroll, Daves, Lisa and Cardelli, J. (2009). Timp-1 Overexpression Promotes

Tumorigenesis of MDA-MB-231 Breast Cancer Cells and Alters Expression of Cancer Promoting Genes in 

vivo. Breast Cancer Research and Treatment (in press).

Cardelli, J. and Skalli, O (2009). Divide and Invade: the Dynamic Cytoskeleton of Glioblastoma Cells.  "Glioblastoma: Molecular Mechanisms of Pathogenesis and Current Therapeutic Strategies." (invited

 review in press)

Steffan, J., Snider, J., Skalli, O., Welbourne, T., and Cardelli, J. (2009). Sodium-Proton Exchangers and RhoA Regulate Acidic Extracellular pH-Induced Peripheral Lysosome Redistribution and Cathepsin B Secretion. Traffic

Bigelow, R., McLarty, J., Elmajian, D., Ankem, M., Smith, M. and Cardelli, J. (2009).Tea Polyphenols

Reduce Serum Levels of PSA, HGF and VEGF in Prostate Cancer Patients and Inhibit Production of HGF and  

VEGF in vitro.  Cancer Prevention Research (In Press)

Snider, J. and Cardelli, J. (2009) Helicobacter pylori Induces Cancer Cell Motility Independent of the c-Met 

Receptor. J. Carcinogenesis (in press).

Milligan, S.A., Burke, P. Steffan, J., Coleman, D., Bigelow, R., Carroll, J., Williams, J. and Cardelli, J. (2009).

The Green Tea Polyphenol, EGCG, Potentiates the Anti-Proliferative Activity of Inhibitors of Growth Factor

Receptors in Non-Small Cell Lung Cancer Cells. Clinical Cancer Research (In Press).

Coleman, D. and Cardelli, J. (2009). Inhibition of Fatty Acid Synthase with the Flavone Luteolin Induces a

Post-transcriptional Loss of c-Met in Prostate Tumor Cells by a Proteosomal/Lysosomal Independent Route.

Molecular Cancer Therapeutics 8:214-224.