Research Assistant Professor

Contact Information:
Email: rscott1@lsuhsc.edu
Office Phone: 318-675-6263
Laboratory Phone: 318-675-4180
Office Fax: 318-675-5764

Education/Training:
Postdoctoral Study, University of North Carolina at Chapel Hill and Louisiana State University Health Sciences Center-Shreveport
Ph.D., Biochemistry, 1997, University of North Carolina at Chapel Hill
B.S., Biochemistry, 1990, Pennsylvania State University

Major Research Interests: 
Mechanisms for Epstein-Barr virus-mediated tumor progression.

The long-term goal of our laboratory is to delineate mechanisms by Epstein-Barr virus (EBV) mediates tumor progression. Two major areas are currently being investigated. The first research area involves understanding how the terminal repeats of EBV influence the expression of latent membrane proteins 1 and 2A, known EBV oncoproteins. The second area involves determining epigenetic changes induced upon EBV infection that can contribute to tumorigenesis, and whether the epigenetic changes are retained upon loss of the virus.

Representative Publications:
Scott, R. S., K. Y. Truong, and J.-M. H. Vos.  1997.  Replication initiation and elongation forks rates within a differentially expressed human multicopy locus in early S phase.  Nucleic Acids Res.   25: 4505-4512.

Scott, R. S., E. J. McMahon, S.M. Pop, E. A. Reap, R. Caricchio, P. L. Cohen, H. S. Earp, and G. K. Matsushima.  2001.  Phagocytosis and clearance of apoptotic cells is mediated by Mer. Nature. 411: 207-211.

Moody C. A., R. S. Scott, T. Su, J.W. Sixbey,  2003.  Length of Epstein-Barr Virus Termini as a Determinant of Epithelial Cell Clonal Emergence.  J. Virol. 77: 8555-61.

Wagner, H-J.  R. S. Scott, D. Buchwald, and J.W. Sixbey.  2004.  Peripheral blood lymphocytes express recombinase activating genes (RAG) 1 and 2 during Epstein-Barr virus (EBV)-induced infectious mononucleosis.  J. Infect Dis. 190(5):979-84.

Scott, R. S., C. A. Moody, and J. Sixbey. 2005. Epstein-Barr virus and oral malignancies. In: Robertson E (ed). Epstein-Barr virus: Pathogenesis, Molecular Biology, and Infection. Horizon Scientific Press/Caister Academic Press, Norfolk, U.K.

Moody, C. A, R. S. Scott, N. Amirghahari, C-A. Nathan, L. S. Young, C. W. Dawson, J. W. Sixbey. 2005. Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A. J Virol.: 79(9):5499-5506.