Chandler Pace

B.S., Biochemistry, 2009, Mississippi State University

M.S., Biochemistry, 2010, Mississippi State University

Rotavirus is a leading cause of gastroenteritis in children and infants. Infection stimulates host cell antiviral gene expression, most notably the production of interferon. It has been previously suggested that rotavirus nonstructural protein NSP1 antagonizes the production of interferon by acting as an E3 ubiquitin ligase and targeting interferon regulatory factorsfor proteasomal degradation. The goal of the project is to discover viral and host proteins that interact with NSP1 in order to understand how NSP1 modulates the innate immune response and determine if NSP1 is a multifunctional protein.

Supported by a grant from the National Institute of General Medical Sciences (P30-GM110703).