Charles Stephens

B.S., Biology, 2012, University of Arkansas

Cancer-associated fibroblasts (CAFs), which produce multiple cytokines, play an important role in prostate tumor invasion and metastasis. Therefore, development of interventions to slow progression of prostate cancer has to consider targeting not only tumor cells, but also the important role of CAFs in cancer progression. The focus of my research is to investigate the signals involved in the differentiation of normal fibroblasts to CAFs and utilizing these signals as potential targets for prostate cancer therapies.

Supported by a grant from the National Institute of General Medical Sciences (P30-GM110703).