Postdoctoral Scientist

Email Address


Dr. Lindy Lutz


Rotavirus is a major pathogen responsible for life-threatening diarrhea in infants and young children worldwide.  Upon viral infection the innate immune response is activated resulting in the production of type I IFNs (IFN-β and IFN-α).  Rotaviruses subvert the innate immune response though inhibition of IFN-β production via nonstructural protein 1 (NSP1).  Previous results suggest that NSP1, a potential E3 ubiquitin ligase, antagonizes the innate immune response by targeting key components of the IFN induction pathway for proteasomal degradation.  The goal of my research is to further investigate NSP1 and its potential E3 ubiquitin ligase activity. 


Supported by a grant from the National Institute of General Medical Sciences (P30-GM110703).