B.S., Biology, 2014, University of Wisconsin-Platteville
Arcanobacterium haemolyticum is a hemolytic Gram positive emerging human pathogen that causes wound infections and pharyngitis. The hemolytic activity is mediated, in part, by arcanolysin (aln/ALN), a member of the cholesterol-dependent cytolysin family of toxins. The recently constructed aln mutant of A. haemolyticum surprisingly retains some hemolytic activity under certain conditions, suggesting existence of a second hemolysin. My specific goals are to: i) investigate specific features necessary for aln expression as well as function of the ALN toxin; ii) identify and characterize the second hemolysin; iii) define the role of ALN in tissue culture and mouse models of infection.
Supported by a grant from the National Institute of General Medical Sciences (P30-GM110703).