Email: Office Phone: 318-675-5756
Laboratory Phone: 318-675-5769
Office Fax: 318-675-5764
Postdoctoral Study, University of Wisconsin
Ph.D., 1977, University of Wisconsin, Molecular Biology
B.S, 1973, University of Illinois, Biochemistry and Molecular Biology
Major Research Interests: Regulation of the invasion and metastasis of cancer cells, and development of novel therapeutics to reduce or prevent tumor invasion and metastatic disease
The major project in my laboratory involves defining the molecular signaling pathways that regulate the invasion and metastasis of cancer cells. Our current primary focus is on breast and prostate cancer. Invasion and metastasis are complicated processes that are poorly understood, and they are the primary reasons many patients with cancer die. Therefore, a better understanding of these processes will lead to the development of more effective therapies. Our approaches range from 1) basic science to define the role of extracellular tumor environment in regulating changes in lysosome trafficking and cell motility, survival, invasion and metastasis, 2) preclinical testing of novel compounds to block these changes, 3) clinical trials to determine if these compounds actually work in patients with cancer and 4) commercialization of successful compounds.
Recent Representative Publications:
Steffan, J., Snider, J., Skalli, O., Welbourne, T., and Cardelli, J. (2009). Sodium-Proton Exchangers and RhoA Regulate Acidic Extracellular pH-Induced Lysosome TraffickingProstate Tumor Cells. Traffic 10: 737-753.
Bigelow, R., McLarty, J., Elmajian, D., Ankem, M., Smith, M. and Cardelli, J. (2009).Tea Polyphenols Reduce Serum Levels of PSA, HGF and VEGF in Prostate Cancer Patients and Inhibit Production of HGF and VEGF in vitro. Cancer Prevention Research 2: 673-682.
Coleman, D. and Cardelli, J. (2009). Inhibition of Fatty Acid Synthase with the Flavone Luteolin Induces a Post-transcriptional Loss of c-Met in Prostate Tumor Cells by a Proteosomal/Lysosomal Independent Route. Mol. Cancer Therapeutics. 8:214-224.
Bigelow, R., Williams, J. Carroll, Daves, Lisa and Cardelli, J. (2009). Timp-1 Overexpression Promotes Tumorigenesis of MDA-MB-231 Breast Cancer Cells and Alters Expression of Cancer Promoting Genes in vivo. Breast Cancer Research and Treatment 117:31-44.
Milligan, S.A., Burke, P. Steffan, J., Coleman, D., Bigelow, R., Carroll, J., Williams, J. and Cardelli, J. (2009). The Green Tea Polyphenol, EGCG, Potentiates the Anti-Proliferative Activity of c-Met and EGFR Inhibitors in Non-Small Cell Lung Cancer Cells. Clinical Cancer Research 15:4885-4894.
Duhon, D. Bigelow, R., Coleman, D., Steffan, J., Yu, C., Steffan, J., Langston, W., Kevil, C., and Cardelli, J. (2010). The Polyphenol EGCCG Affects Lipid Rafts to Block Activation of the c-Met Receptor in Prostate Cancer Cells. Molecular Carcinogenesis 49: 739-749.
Steffan, J., Williams, B., Welbourne, T. and Cardelli, J. (2010). HGF-Induced Invasion by Prostate Tumor Cells Requires anterograde lysosome trafficking and activity of Na+- H+ exchangers. J. Cell Sci. 123: 1151- 1159.
Steffan, J. and Cardelli, J. (2010). Thiazolidinediones Induce Rab7-RILP-MAPK-dependent Juxtanuclear Lysosome Aggregation and Reduce Tumor Cell Invasion. Traffic 11: 274-286.
Steffan, J, Coleman, D., and Cardelli, J. (2011). The HGF-Met Signaling Axis: Emerging Themes and Targets of Inhibition. In Current Protein and Peptide Science.
All Publications: Pubmed