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Assistant Professor , Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe

Contact Information:
Email: Office Phone: 318-342-1747
Office Fax: 318-342-1737

Postdoctoral training, National Institutes of Health (NIH)

Ph.D., 1999, Immunology and Microbiology, Wayne State University, Detroit, Michigan.

B.S., 1989, Plant Science, National Taiwan University, Taipei, Republic of China.

Major Research Interests:  
Molecular aspects of herpes simplex 1 latency and reactivation.

Representative Publications:

Pinnoji RC, Bedadala GR, George B, Holland TC, Hill JM, Hsia SC.  Repressor Element-1 Silencing Transcription Factor/Neuronal Restrictive Silencer Factor (REST/NRSF) Can Regulate HSV-1 IMmediate-Early Transcription via Histone Modification.  Virol J. 2007 [In Press].

Bedadala GR, Pinnoji RC, Hsia SC. Early Growth Response gene 1 (Egr-1) regulates HSV-1 ICP4 and ICP22 gene expression. Cell Res. 2007 May 15; [Epub ahead of print]
PMID: 17

Buchholz DR, Hsia SC, Fu L, Shi YB. A dominant-negative thyroid hormone receptor blocks amphibian metamorphosis by retaining corepressors at target genes. Mol Cell Biol. 2003 Oct;23(19):6750-8. PMID: 12972595

Hsia SC, Tomita A, Obata K, Paul B, Buchholz D, Shi YB. Role of chromatin disruption and histone acetylation in thyroid hormone receptor action: implications in the regulation of HIV-1 LTR.
Histol Histopathol. 2003 Jan;18(1):323-31. Review.
PMID: 12507309

Hsia SC, Shi YB. Chromatin disruption and histone acetylation in regulation of the human immunodeficiency virus type 1 long terminal repeat by thyroid hormone receptor.
Mol Cell Biol. 2002 Jun;22(12):4043-52.
PMID: 12024018

Shi YB, Fu L, Hsia SC, Tomita A, Buchholz D. Thyroid hormone regulation of apoptotic tissue remodeling during anuran metamorphosis.
Cell Res. 2001 Dec;11(4):245-52. Review.
PMID: 11787769

Hsia SC, Wang H, Shi YB. Involvement of chromatin and histone acetylation in the regulation of HIV-LTR by thyroid hormone receptor.
Cell Res. 2001 Mar;11(1):8-16.
PMID: 11305329

Sachs, LM, Jones, P, Hsia, S, and Shi, Y.  Chromatin remodeling and developmental gene regulation by thyroid hormone receptor.  Gene Therapy and Molecular Biology (5) 101-110 (2000).

Hamouda T, McPhee R, Hsia SC, Read GS, Holland TC, King SR. Inhibition of human immunodeficiency virus replication by the herpes simplex virus virion host shutoff protein.
J Virol. 1997 Jul;71(7):5521-7.
PMID: 9188626




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