Associate Professor

Contact Information:
Email: Office Phone: 318-675-6263
Laboratory Phone: 318-675-4180
Office Fax: 318-675-5764

Major Research Interests:  Mechanisms for Epstein-Barr virus-mediated tumor progression


Epstein-Barr virus (EBV) is a prevalent herpesvirus that infects greater than 95% of the world’s adult population, usually without consequence. However, in some cases, the virus is associated with the development of lymphoid and epithelial malignancies. The long-term goal of our laboratory is to delineate mechanisms by which EBV mediates tumor progression. Two major areas are currently being investigated. The first research area involves understanding how epigenetic alterations on the virus and host genome that contribute to tumorigenesis. The second area involves understanding interactions between Epstein-Barr virus and human papillomavirus in oral cancer.


Representative Publications:

Moody CA, Scott RS, Su T, Sixbey JW.  2003.  Length of Epstein-Barr Virus termini as a determinant of epithelial cell clonal emergenceJ Virol.; 77: 8555-61. PMCID: PMC165260

Scott R S, Moody CA, and Sixbey JW.  2005.  Epstein-Barr virus and oral malignancies.  In: Robertson E (ed). Epstein-Barr virus: Pathogenesis, Molecular Biology, and Infection. Horizon Scientific Press/Caister Academic Press, Norfolk, U.K.

Jiang R, Scott RS, and Hutt-Fletcher L. 2006.   Epstein-Barr virus shed in saliva is high in B-cell-tropic glycoprotein gp42.  J Virol.  80(14): 7281-7283.  PMCID: PMC1489022

Ikuta K, Srinivas SK, Schacker T, Miyagi JI. Scott RS, Sixbey JW.  2008.  Points of Recombination in P3HR-1-Derived Heterogeneous (het) DNA as an Index to EBV DNA Recombinogenic Events In VivoJ Virol. 82(23):11516-25. PMCID: PMC2583645

Repic AM, Scott RS, Shi M, Sixbey JW. 2010. Augmented LMP1 Expression from Epstein-Barr Virus (EBV) Episomes with Minimal Terminal Repeats.  J. Virol. 84(5):2236-44.   PMCID: PMC2820940

Ikuta K., Ding M,  Zhang F, Sixbey JW, and  Scott RS.  2011.  Epithelial Cell Retention of Transcriptionally Active, P3HR1-Derived Heterogeneous (het) EBV DNA with Concurrent Loss of Parental Virus.  J Virol. 85(15): 7634-7543. PMCID: PMC3147926

Queen KJ, Shi M, Zhang F, Cvek U and Scott RS. 2013. Epstein–Barr virus-induced epigenetic alterations following transient infection. Int. J. Cancer. 132(9):2076-86. PMCID: PMC3578144

Shi M, Davis TO, Gan Y, and Scott RS.  2013.  Downregulation of a polyamine regulator, spermidine/spermine N1-acetyltransferase (SSAT), by Epstein-Barr virus in a Burkitt’s Lymphoma Cell Line. Virus Res. 2013 Oct;177(1):11-21. PMID: 23891576

Birdwell CE, Queen KJ, Rollyson P, Kilgore P, Trutschl M, Cvek U, Scott RS.  2014. Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes.  J Virol. 88(19):11442-58. PMCID: PMC4178815

Trutschl M, Kilgore PCSR, Scott RS, Birdwell CE and Cvek U.  2014. Detection and Employment of Biological Sequence Motifs. In Big Data Analytics in Bioinformatics and Healthcare. IGI Global. 86-116.

Jiang R, Ekshyyan O, Moore-Medlin T, Rong X , Nathan S, Gu X, Abreo F,   Rosenthal EL, Shi M, Guidry JT, Scott  RS, Hutt-Fletcher LM, Nathan CO.  2015. Association between HPV/EBV co-infection and oral carcinogenesis. J Oral Pathol Med. 44(1):28-36. PMCID: PMC4286485

All Publications: Pubmed