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Contact Information:
Email: Office Phone: 318-675-4272
Laboratory Phone: 318-675-4180
Office Fax: 318-675-5764

Infectious Diseases Fellowship, 1980-83, University of North Carolina Lineberger Comprehensive Cancer Center
Medicine Residency, 1977-80, University of Maryland Hospital
M.D., 1977, University of Arkansas for Medical Sciences
B.A., Political Science, 1966, University of Maryland at College Park

Major Research Interests:  
EBV Pathogenesis

The notion that viruses may be responsible for initiation of disease, yet fail to persist in affected tissues, is frequently raised in the context of chronic diseases of unknown etiology.  We are investigating Epstein-Barr virus pathogenesis and the sporadic nature of its association with human cancers:  gastric carcinoma, head and neck squamous cell carcinoma, Burkitt's lymphoma, Hodgkin's lymphoma, leiomyosarcoma, and central nervous system lymphoma.  We are testing models of EBV pathogenesis more compatible with such an unpredictable association of virus with tumor that include a temporal sequence of 1) cell transformation; 2) EBV infection of a pre-existing neoplasm; 3) EBV driven tumor progression; 4) viral redundancy and loss from infected tissue.

Representative Publications:
Sixbey, J. W.
and Q. Y. Yao. 1992. Immunoglobulin A-induced shift of Epstein-Barr virus tissue tropism. Science. 255:1578-1580.

Srinivas, S. K. and J. W. Sixbey. 1995. Epstein-Barr virus induction of recombinase-activating genes RAG1 and RAG2, J. Virol . 69:8155-8158.

Razzouk, B. I., S. Srinivas, C. E. Sample, V. Singh, and J. W. Sixbey. 1996. Epstein-Barr virus DNA recombination and loss in sporadic Burkitt's lymphoma. J. Infect. Dis. 173:529-535.

Chodosh, J., V. Holder, Y. J. Gan, A. Belgaumi, J. Sample, and J. W. Sixbey. 1998. Eradication of latent Epstein-Barr virus by hydroxyurea alters the growth transformed cell phenotype. J. Infect. Dis. 177:1194-1201.

Srinivas, S., J. Sample, and J. W. Sixbey. 1998. Spontaneous loss of viral episomes accompanying Epstein-Barr virus reactivation in a Burkitt lymphoma cell line. J. Infect. Dis. 177:1705-1709.

Chodosh, J., Y-J. Gan, V. P. Holder, J. W. Sixbey. 2000. Patterned entry and egress by Epstein Barr virus in polarized CR2-positive epithelial cells. Virology. 266:387-396.

Gan, Y. J., B. I. Razzouk, T. Su, J. W. Sixbey. 2002. A defective, rearranged Epstein-Barr virus genome in EBER-positive and -negative Hodgkin's disease. Am. J. Pathol. 160:781-6.

Moody, C. A., R. S. Scott, T. Su, J. W. Sixbey. 2003. Length of Epstein-Barr virus termini as a determinant of epithelial cell clonal emergence.   J. Virol.  77:8555-61.

Wagner H.J., R.S. Scott, D. Buchwald, J.W. Sixbey.  2004. Peripheral blood lymphocytes express recombination-activating genes (RAG) 1 and 2 during Epstein-Barr virus (EBV)-induced infectious mononucleosis.  J. Infect Dis. 190:979-984.

Stewart S, C.W. Dawson, K. Takada, J. Curnow, C.A. Moody, Sixbey JW, Young LS. 2004.  Epstein-Barr virus-encoded LMP2A regulates viral and cellular gene expression by modulation of the NF-?B transcription factor pathway . Proc Natl Acad Sci USA. 101:15730-15735.

Bollard CM, L. Aguilar, K.C. Straathof, B. Gahn, M.H. Huls, A. Rousseau, Sixbey J, M.V. Gresik, G. Carrum, M. Hudson, D. Dilloo, A. Gee, M.K. Brenner, C.M. Rooney, H.E. Heslop. 2004. Cytotoxic T lymphocyte therapy for EBV-positive Hodgkin's disease . J. Exp Med. 200:1623-1633.

Cerimele F, T. Battle T, R. Lynch, D. A. Frank, E. Murad, C. Cohen C, N. Macaron, J. Sixbey, K. Smith, R.S. Watnick, A. Eliopoulos, B. Shehata, J.L. Arbiser. 2005. Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr virus (EBV)-positive versus EBV-negative Burkitt’s lymphoma. Proc Natl Acad Sci USA. 102:175-179.


Moody C.A., R.S. Scott, N. Amirghahari, C.A. Nathan, L.S. Young, C.W. Dawson, J.W. Sixbey. 2005. Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A. J. Virol. 79:5499-5506.



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